Currently there are a dozen or so of new vaccine candidates in clinical trials for prevention of tuberculosis (TB) and each formulation attempts to elicit protection by enhancement of cell-mediated immunity (CMI).In contrast, most approved vaccines against other bacterial pathogens are believed to mediate protection by eliciting antibody responses.
Proteases represent common targets in combating infectious diseases, including COVID-19.The 3-chymotrypsin-like protease (3CLpro) is a validated molecular target for COVID-19, and it is key for developing potent and selective inhibitors for inhibiting viral replication of SARS-CoV-2.In this review, we discuss structural relationships and diverse su
N-Dodecyloxymethylene-N-methylpiperidinium chloride (DMMP) and N-dodecyloxyme-thylene-N-methylmorpholinium chloride (DMMM) retarded germination of seeds of 9 cultivated plant species when applied at a concentration of fanimation triaire 52 10-3 M, and inhibited germination at a concentration of 10-2 M.The exceptions were represented by Lepidium sat